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Hugo Sachs Elektronik rodent shocker generator type 221
Rodent Shocker Generator Type 221, supplied by Hugo Sachs Elektronik, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/rodent+shocker+generator+type+221/rodent+shocker+generator+type+221/pmc11677119-246-4-9
Average 90 stars, based on 1 article reviews
rodent shocker generator type 221 - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Synthesis, molecular modeling studies and anticonvulsant activity of certain (1-(benzyl (aryl) amino) cyclohexyl) methyl esters.
Article Snippet: Accepted Manuscript Synthesis, Molecular Modeling Studies and Anticonvulsant Activity of certain (1-(Benzyl (aryl) amino) cyclohexyl) methyl esters Walaa Hamada Abd-Allah, Mona Elsayed Aboutabl, Mohamed Nabil AboulEnein, Aida Abdel Sattar El-Azzouny PII: S0045-2068(16)30341-8 DOI: http://dx.doi.org/10.1016/j.bioorg.2017.01.021 Reference: YBIOO 2010 To appear in: Bioorganic Chemistry Received Date: 4 November 2016 Revised Date: 22 December 2016 Accepted Date: 29 January 2017 Please cite this article as: W. Hamada Abd-Allah, M. Elsayed Aboutabl, M. Nabil Aboul-Enein, A. Abdel Sattar El-Azzouny, Synthesis, Molecular Modeling Studies and Anticonvulsant Activity of certain (1-(Benzyl (aryl) amino) cyclohexyl) methyl esters, Bioorganic Chemistry (2017), doi: http://dx.doi.org/10.1016/j.bioorg.. 2017.01.021 This is a PDF file of an unedited manuscript that has been accepted for publication.. As a service to our customers we are providing this early version of the manuscript.

Article Title: Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model.
Article Snippet: Purpose: The aim of this study was to assess the anticonvulsant potency of 6 various benzylamide derivatives [i.e., nicotinic acid benzylamide (Nic-BZA), picolinic acid 2-fluoro-benzylamide (2F-Pic-BZA), picolinic acid benzylamide (Pic-BZA), (RS)-methyl-alanine-benzylamide (Me-Ala-BZA), isonicotinic acid benzylamide (Iso-Nic-BZA), and (R)-N-methyl-proline-benzylamide (Me-Pro-BZA)] in the threshold for maximal electroshock (MEST)-induced seizures in mice.. Methods: Electroconvulsions (seizure activity) were produced in mice by means of a current (sine-wave, 50 Hz, 500 V, strength from 4 to 18 mA, ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the endpoint).. Results: Nic-BZA, 2F-Pic-BZA, Pic-BZA, Me-Ala-BZA, Iso-Nic-BZA, and Me-Pro-BZA administered systemically (ip) in a dose-dependent manner increase the threshold for maximal electroconvulsions in mice.

Article Title: Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
Article Snippet: In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was synthesized and their anticonvulsant potential was evaluated.. All the compounds under investigation exhibited anticonvulsant activity in both scPTZ and MES tests.. In phase II anticonvulsant study, the trimethoxy phenyl derivative 9a evoked the highest potency among the tested compounds in scPTZ test.

Article Title: The anticonvulsant and anti-plasmid conjugation potential of Thymus vulgaris chemistry: An in vivo murine and in vitro study.
Article Snippet: .. Maximal electroshock seizure test An alternating current stimulation (sine-wave, 25 mA, 50 Hz, 500 V, 0.2 s stimulus duration) delivered through ear-clip electrodes by a Rodent Shocker generator (Type 221, Hugo Sachs Elektronik, Freiburg, Germany) was used to produced electroconvulsions. ..

Article Title: Chronic Treatment with Oxcarbazepine Attenuates Its Anticonvulsant Effect in the Maximal Electroshock Model in Mice
Article Snippet: .. Electroconvulsions were produced by means of alternating current (sine wave, 0.2 stimulus duration, frequency of 50 Hz, maximum stimulation voltage of 500 V, and fixed current strength of 25 mA) delivered via ear-clip electrodes by a rodent shocker generator (Type 221, Hugo Sachs Elektronik, Freiburg, Germany). ..

other:

Article Title: The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Article Snippet: Purpose: The aim of this study was to evaluate the effects of 1-day, 7-day and 14-day administrations of cimetidine on the anticonvulsant activity of conventional antiepileptic drugs (AEDs; valproate, carbamazepine, phenytoin and phenobarbital) against maximal electroshock (MES)-induced convulsions in mice.. Methods: Electroconvulsions were evoked in Albino Swiss mice by a current delivered via ear-clip electrodes.. In addition, the effects of cimetidine, AEDs alone and their combinations were studied on performance and long-term memory tests.

Article Title: Subchronic Treatment with CBZ Transiently Attenuates Its Anticonvulsant Activity in the Maximal Electroshock-Induced Seizure Test in Mice
Article Snippet: The specifications of the rodent shocker generator (Type 221, Hugo Sachs Elektronik, Freiburg, Germany) and the comprehensive methodology were previously outlined by Borowicz-Reutt and Banach [ ].

Activity Assay:

Article Title: Assessment of the anticonvulsant potency of various benzylamide derivatives in the mouse maximal electroshock-induced seizure threshold model.
Article Snippet: Purpose: The aim of this study was to assess the anticonvulsant potency of 6 various benzylamide derivatives [i.e., nicotinic acid benzylamide (Nic-BZA), picolinic acid 2-fluoro-benzylamide (2F-Pic-BZA), picolinic acid benzylamide (Pic-BZA), (RS)-methyl-alanine-benzylamide (Me-Ala-BZA), isonicotinic acid benzylamide (Iso-Nic-BZA), and (R)-N-methyl-proline-benzylamide (Me-Pro-BZA)] in the threshold for maximal electroshock (MEST)-induced seizures in mice.. Methods: Electroconvulsions (seizure activity) were produced in mice by means of a current (sine-wave, 50 Hz, 500 V, strength from 4 to 18 mA, ear-clip electrodes, 0.2-s stimulus duration, tonic hindlimb extension taken as the endpoint).. Results: Nic-BZA, 2F-Pic-BZA, Pic-BZA, Me-Ala-BZA, Iso-Nic-BZA, and Me-Pro-BZA administered systemically (ip) in a dose-dependent manner increase the threshold for maximal electroconvulsions in mice.

Article Title: Effect of acute and chronic exposure to lovastatin on the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Article Snippet: .. Seizure activity in mice was evoked by applying an alternating current (50 Hz; 0.2s; 500 V) delivered via ear-clip electrodes from a rodent shocker generator (type 221; Hugo Sachs Elektronik, Freiburg, Germany). ..

Mouse Assay:

Article Title: Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
Article Snippet: In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was synthesized and their anticonvulsant potential was evaluated.. All the compounds under investigation exhibited anticonvulsant activity in both scPTZ and MES tests.. In phase II anticonvulsant study, the trimethoxy phenyl derivative 9a evoked the highest potency among the tested compounds in scPTZ test.

Injection:

Article Title: Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
Article Snippet: In this work a set of novel derivatives of parabanic acid 9a-d, 12a-d and 13a-d was synthesized and their anticonvulsant potential was evaluated.. All the compounds under investigation exhibited anticonvulsant activity in both scPTZ and MES tests.. In phase II anticonvulsant study, the trimethoxy phenyl derivative 9a evoked the highest potency among the tested compounds in scPTZ test.



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